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KMID : 1143420160090220399
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Public Health Weekly Report
2016 Volume.9 No. 22 p.399 ~ p.404
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Effect of Early HIV Diagnosis by Introduction of Acute HIV Confirmatory Testing Algorithm
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Kim Kyung-Chang
Sim Hyo-Jung
Park Min-A
Choi Byeong-Sun
Kang Chun
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Abstract
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Background: KCDC introduced the more accurate laboratory diagnosis algorithm of acute HIV-1 infection with HIV virologic (non-Antibody) tests, such as, HIV nucleic acid (DNA or RNA) test and HIV p24 antigen test including neutralization assay in 2015. In this study, the effectiveness of acute HIV confirmatory testing algorithm was analyzed.
Methods: The number and the duration of diagnosis for HIV indeterminate samples (INDs) in 2014 and 2015 were collected. The rate of the duration of diagnosis in each HIV IND was calculated by dividing the total duration of diagnosis by the total IND numbers. Fiebig stages were used to classify acute (primary) HIV infection.
Results: The number of HIV INDs in 2014 and 2015 were 294 and 222, respectively. There was 25 % decrease from 2014 to 2015. The mean duration of diagnosis for an HIV IND in 2015 (11.5 days) declined by 10 days compared with 21.4 days in 2014.
Conclusion: These results indicate that the introduction of new HIV diagnostic algorithm can be a more effective HIV/AIDS preventive policy because it reduces the number and the diagnostic time of INDs, dramatically.
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KEYWORD
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